2024 (7)

137. Cobalt-Catalyzed Enantioselective Dicarbofunctionalization of Acrylates
Jie-Jun Li
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Yi Xu
• , Xiao-Long Wan, Qi-Long Shen*


• Li, J.; Xu, Y.; Wan, X.; Shen, Q.*

ACS Catal. 2024, 14, 15221–15236.
10.1021/acscatal.4c03670

136. Phase-Transfer-Shuttle Generated in situ Enables Novel S_N1-Type Fluorination of Sulfonium Ylide with Hydrofluoric Acid
Yi-Sa Xiao
• , Rui Wang, Zhao-Xuan Xu, Qun-Chao Zhao, Tao Dong, Ren-Yi Pang,
Long Lü
• , Qi-Long Shen*


• Xiao, Y.; Wang, R.; Xu, Z.; Zhao, Q.; Dong, T.; Pang, R.; Lü, L.; Shen, Q.*

Sci. China: Chem. 2024, xx, xxx–xxx.
10.1007/s11426-024-2240-5
(https://www.sciengine.com/SCC/doi/10.1007/s11426-024-2240-5)

135. Oxidative Substitution of Organocopper(II) by a Carbon-Centered Radical
Yue-Cheng Weng
• ,
Yu-Xuan Jin
• ,
Jian Wu
• ,
Xue-Bing Leng
• , Xiao-Bing Lou, Fu-Shan Geng, Bing-Wen Hu,
Bo-Tao Wu
• *, Qi-Long Shen*


• Weng, Y.; Jin, Y.; Wu, J.; Leng, X.; Lou, X.; Geng, F.; Hu, B.; Wu, B.*; Shen, Q.*

J. Am. Chem. Soc. 2024, 146, 23555–23565.
10.1021/jacs.4c07552

134. Synthesis and Application of Well-Defined [Ph₄P]⁺[Cu(CF₂CF₃)₂]⁻ Complex as a Versatile Pentafluoroethylating Reagent

• Tao Dong, Qi-Long Shen*, Gavin Chit Tsui*


• Dong, T.; Shen, Q.*; Tsui, G. C.*

Chem. Sci. 2024, 15, 11550–11556.
10.1039/D4SC02075H

133. YlideFluor-CF₂Cl: A Shelf-Stable, Versatile Electrophilic or Radical Chlorodifluoromethylating Reagent
Tian Zhang
• , Yu-Han Zhang,
Zi-Meng Li
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Bo-Tao Wu
• , Qi-Long Shen*


• Zhang, T.; Zhang, Y.; Li, Z.; Wu, B.; Shen, Q.*

Org. Chem. Front. 2024, 11, 3924–3928.
10.1039/D4QO00600C

132. [(tBu₂PhP)Ag(μ-OCF₃)]₂: A Thermally Stable, Light-Insensitive Nucleophilic Reagent for Trifluoromethoxylation

• Dao-Qian Chen,
Yong-Rui Luo
• ,
Long Lü
• *, Qi-Long Shen*


• Chen, D.; Luo, Y.; Lü, L.*; Shen, Q.*

Organometallics 2024, xx, xxx–xxx.
10.1021/acs.organomet.4c00073

131. Access to Versatile Functionalized Cu(III) Complexes Enabled by Direct Transmetalation to Well-Defined Copper(III) Fluoride Complex Me₄N⁺[Cu(CF₃)₃F]⁻
Guang-Yu Wang
• , Huai-Yuan Li,
Xue-Bing Leng
• ,
Long Lü
• , Qi-Long Shen*


• Wang, G.; Li, H.; Leng, X.; Lü, L.; Shen, Q.*

Chin. J. Chem. 2024, 42, 1107–1113.
10.1002/cjoc.202400041
(This paper has been honored with the "NHU-CJC Innovation Award.")

2023 (9)

130. nBu₄N⁺[Ag^I(CF₃)₂]⁻: Trifluoromethylated Argentate Derived from Fluoroform and Its Reaction with (Hetero)Aryl Diazonium Salts
Ze-Hai Lu
• , Lin-Hua Wang, Matthew Hughes, Stephen Smith, Qi-Long Shen*


• Lu, Z.; Wang, L.; Hughes, M.; Smith, S.; Shen, Q.*

Org. Lett. 2024, 26, 2773–2777.
10.1021/acs.orglett.3c02804

129. Oxidative Addition of an Alkyl Halide to Form a Stable Cu(III) Product
Yong-Rui Luo
• , Yu-Li Li,
Jian Wu
• ,
Xiao-Song Xue
• *,
John F. Hartwig
• *, Qi-Long Shen*


• Luo, Y.; Li, Y.; Wu, J.; Xue, X.*; Hartwig, J. F.*; Shen, Q.*

Science 2023, 381, 1072–1079.
10.1126/science.adg9232

128. Scalable Synthesis of the Shelf-Stable Radical Difluoromethylthiolation Reagent S-(Difluoromethyl)benzenesulfonothioate PhSO₂SCF₂H

• Xin Qiu, Wen-Run Lou, Sheng-Xue Zhang, Sheng-Ya-Jun Meng, Yong Guo, Xiao-Yu Ma*, Chao Liu*, Qi-Long Shen*


• Qiu, X.; Lou, W.; Zhang, S.; Meng, S.; Guo, Y.; Ma, X.*; Liu, C.*; Shen, Q.*

Org. Process Res. Dev. 2023, 27, 1104–1110.
10.1021/acs.oprd.3c00087

127. [(SIPr)Ag(CF₂H)]: A Shelf-Stable, Versatile Difluoromethylation Reagent

• Hai-Wei Zhao,
Yang Gu
• , Qi-Long Shen*


• Zhao, H.; Gu, Y.; Shen, Q.*

Chem. Rec. 2023, 23, e202300124.
10.1002/tcr.202300124

126. A Versatile, Electrophilic Reagent for Monofluoromethylthiolation

• Rui Wang,
Long Lü
• *, Qi-Long Shen*


• Wang, R.; Lü, L.*; Shen, Q.*

Chin. J. Chem. 2023, 41, 2317–2329.
10.1002/cjoc.202300164

125. Diimidazolium Salt HBDIM: An Easily Available, Low-Cost, CageCarbene Precursor with Broad Applications in Transition Metal-Catalyzed Reactions

• Wei-Kang Jiang,
Wei-Chen Huang
• , Mei-Chen Xu,
Xue-Bing Leng
• ,
Long Lü
• , Qi-Long Shen*


• Jiang, W.; Huang, W.; Xu, M.; Leng, X.; Lü, L.; Shen, Q.*

Chem. Eur. J. 2023, 29, e202300991.
10.1002/chem.202300991

124. A Toolbox of Reagents for Trifluoromethylthiolation: From Serendipitous Findings to Rational Design

• Qi-Long Shen*


• Shen, Q.*

J. Org. Chem. 2023, 88, 3359–3371.
10.1021/acs.joc.2c02777

123. Copper-Catalyzed Trifluoromethylation of (Hetero)aryl Boronic Acid Pinacol Esters with YlideFluor

• Jing Liu,
Yi-Sa Xiao
• , Jian Hao*, Qi-Long Shen*


• Liu, J.; Xiao, Y.; Hao, J.*; Shen, Q.*

Org. Lett. 2023, 25, 1204–1208.
10.1021/acs.orglett.3c00206

122. Visible-Light-Promoted Direct Trifluoromethylation of Tryptophan-Containing Oligapeptides with YlideFluor

• Jing Liu, Jian Hao*, Qi-Long Shen*


• Liu, J.; Hao, J.*; Shen, Q.*

Chin. J. Org. Chem. 2023, 43, 1517–1524.
10.6023/cjoc202209018

2022 (9)

121. C–H Bond Fluorination
Yi-Fa Yang
• , Qi-Long Shen*


• Yang, Y.; Shen, Q.*

Handbook of CH-Functionalization
10.1002/9783527834242.chf0177

120. Preparation, Characterization and Reactivity of Trifluoromethoxy Palladium(II) Complexes
Song-Song Xu
• , Ying-Bo Shao, Han-Liang Zheng,
Xue-Bing Leng
• ,
Xiao-Song Xue
• *, Qi-Long Shen*


• Xu, S.; Shao, Y.; Zheng, H.; Leng, X.; Xue, X.*; Shen, Q.*

New J. Chem. 2022, 46, 20760–20767.
10.1039/D2NJ04198G

119. [Ph₄P]⁺[Cu(CF₂H)₂]⁻: A Powerful Difluoromethylating Reagent Inspired by Mechanistic Investigation

• Hai-Wei Zhao,
Xue-Bing Leng
• , Wei Zhang, Qi-Long Shen*


• Zhao, H.; Leng, X.; Zhang, W.; Shen, Q.*

Angew. Chem. Int. Ed. 2022, 61, e202210151.
10.1002/anie.202210151

118. Bromodifluoromethyl Sulfonium Ylide: an Easily Available Electrophilic Bromodifluoromethylating Reagent for Bromodifluoromethylation of Styrenes and Heteroarenes by Visible-Light-Promoted Photoredox

• Yu-Han Zhang,
Jian-Sheng Zhu
• , Qi-Long Shen*


• Zhang, Y.; Zhu, J.; Shen, Q.*

J. Fluorine Chem. 2022, 261–262, 110021.
10.1016/j.jfluchem.2022.110021

117. Neutral Five-Coordinate Arylated Copper(III) Complex: Key Intermediate in Copper-Mediated Arene Trifluoromethylation
Guang-Yu Wang
• , Man Li,
Xue-Bing Leng
• ,
Xiao-Song Xue
• *, Qi-Long Shen*


• Wang, G.; Li, M.; Leng, X.; Xue, X.*; Shen, Q.*

Chin. J. Chem. 2022, 40, 1924–1930.
10.1002/cjoc.202200230

116. A Fruitful Decade of Organofluorine Chemistry: New Reagents and Reactions

• Feng-Ling Qing*, Xin-Yuan Liu*, Jun-An Ma*, Qi-Long Shen*, Qiu-Ling Song*, Ping-Ping Tang*


• Qing, F.*; Liu, X.*; Ma, J.*; Shen, Q.*; Song, Q.*; Tang, P.*

CCS Chem. 2022, 4, 2518–2549.
10.31635/ccschem.022.202201935

115. Recent Progress on Trifluoromethylthiolation of (Hetero)Aryl C–H Bonds with Electrophilic Trifluoromethylthiolating Reagents
Chun-Fa Xu
• , Shi-Ping Wang, Qi-Long Shen*


• Xu, C.; Wang, S.; Shen, Q.*

ACS Sustainable Chem. Eng. 2022, 10, 6889–6899.
10.1021/acssuschemeng.2c01006

114. Kilogram-Scale Preparation of the Easily Available, Low-Cost Electrophilic Trifluomethylating Reagent YlideFluor

• Rui-Chao Yao, Yi-Jing Ling, Wen-Bo Chen,
Long Lü
• , Qi-Long Shen*


• Yao, R.; Ling, Y.; Chen, W.; Lü, L.; Shen, Q.*

Org. Process Res. Dev. 2022, 26, 299–306.
10.1021/acs.oprd.1c00381

113. Stereoselective Formation of Z-Monofluoroalkenes by Nickel-Catalyzed Defluorinative Coupling of gem-Difluoroalkenes with Lithium Organoborates
Yi-Sa Xiao
• ,
Wei-Chen Huang
• , Qi-Long Shen*


• Xiao, Y.; Huang, W.; Shen, Q.*

Chin. Chem. Lett. 2022, 33, 4277–4280.
10.1016/j.cclet.2022.01.020

2021 (11)

112. (1S)-(−)-N-Monofluoromethylthio-7,7-dichloro-2,10-camphorsultam: An Optically Pure Reagentfor Asymmetric Monofluoromethylthiolation
He Zhang
• , Qi-Long Shen*


• Zhang, H.; Shen, Q.*

Tetrahedron 2021, 101, 132508.
10.1016/j.tet.2021.132508

111. Mechanistic Insight into Copper-Mediated Trifluoromethylation of Aryl Halides: The Role of CuI

• He Liu,
Jian Wu
• ,
Yu-Xuan Jin
• ,
Xue-Bing Leng
• , Qi-Long Shen*


• Liu, H.; Wu, J.; Jin, Y.; Leng, X.; Shen, Q.*

J. Am. Chem. Soc. 2021, 143, 14367–14378.
10.1021/jacs.1c07408

110. Radiosynthesis of [¹⁸F]ArylSCF₂H Using Aryl Boronic Acids, S-(Chlorofluoromethyl)benzenesulfonothioate and [¹⁸F]Fluoride

• Qun-Chao Zhao, Patrick G. Isenegger, Thomas C. Wilson, Jeroen B. I. Sap, Florian Guibbal,
Long Lü
• , Véronique Gouverneur*, Qi-Long Shen*


• Zhao, Q.; Isenegger, P. G.; Wilson, T. C.; Sap, J. B. I.; Guibbal, F.; Lü, L.; Gouverneur, V.*; Shen, Q.*

CCS Chem. 2021, 3, 1921–1928.
10.31635/ccschem.020.202000399

109. Difluoromethylthiolator: A Toolbox of Reagents for Difluoromethylthiolation
Jiang Wu
• , Qi-Long Shen*


• Wu, J.; Shen, Q.*

Acc. Chem. Res. 2021, 54, 2946–2958.
10.1021/acs.accounts.1c00252

108. C(sp²)-CF₃ Reductive Elimination from Well-Defined Argentate(III) Complexes [nBu₄N][Ag(Ar)(CF₃)₃]
Ze-Hai Lu
• , Shi-Han Liu,
Yu Lan
• *,
Xue-Bing Leng
• , Qi-Long Shen*


• Lu, Z.; Liu, S.; Lan, Y.*; Leng, X.; Shen, Q.*

Organometallics 2021, 40, 1713–1718.
10.1021/acs.organomet.1c00195

107. Well-defined Organometallic Copper(III) Complexes: Preparation, Characterization and Reactivity

• He Liu, Qi-Long Shen*


• Liu, H.; Shen, Q.*

Coord. Chem. Rev. 2021, 442, 213923.
10.1016/j.ccr.2021.213923

106. Photosensitizer-Free Visible-Light-Promoted Trifluoromethylation of Imidazo[1,2-a]pyridines

• Rui-Chao Yao, Wen-Bo Chen*, Qi-Long Shen*


• Yao, R.; Chen, W.*; Shen, Q.*

Chin. J. Org. Chem. 2021, 41, 2684–2692.
10.6023/cjoc202103004

105. C(sp²)–X (X = Cl, Br, and I) Reductive Eliminations from Well-Defined Gold(III) Complexes: Concerted or Dissociation Pathways?
Kai Kang
• , Shi-Han Liu, Chun-Hui Xu,
Ze-Hai Lu
• , Shuan-Shuan Liu,
Xue-Bing Leng
• ,
Yu Lan
• *, Qi-Long Shen*


• Kang, K.; Liu, S.; Xu, C.; Lu, Z.; Liu, S.; Leng, X.; Lan, Y.*; Shen, Q.*

Organometallics 2021, 40, 2231–2239.
10.1021/acs.organomet.0c00784

104. Rational Design and Development of Low-Price, Scalable, Shelf-Stable and Broadly Applicable Electrophilic Sulfonium Ylide-Based Trifluoromethylating Reagents

• Ya-Fei Liu, Yi-Jing Ling,
Hang-Ming Ge
• ,
Long Lü
• *, Qi-Long Shen*


• Liu, Y.; Ling, Y.; Ge, H.; Lü, L.*; Shen, Q.*

Chin. J. Chem. 2021, 39, 1667–1682.
10.1002/cjoc.202100107

103. Difluoromethylation of Alkyl Bromides and Iodides with TMSCF₂H

• Hai-Wei Zhao, Chang-Hui Lu, Simon Herbert, Wei Zhang, Qi-Long Shen*


• Zhao, H.; Lu, C.; Herbert, S.; Zhang, W.; Shen, Q.*

J. Org. Chem. 2021, 86, 2854–2865.
10.1021/acs.joc.0c02783

102. Introduction of Trifluoromethylthio Group into Organic Molecules
Hang-Ming Ge
• , He Liu, Qi-Long Shen*


• Ge, H.; Liu, H.; Shen, Q.*

Organofluorine Chemistry: Synthesis, Modeling, and Applications.
10.1002/9783527825158.ch4

2020 (9)

101. Synergistic Lewis Acid and Photoredox-Catalyzed Trifluoromethylative Difunctionalization of Alkenes with Selenium Ylide-Based Trifluoromethylating Reagent
Hang-Ming Ge
• ,
Bo-Tao Wu
• , Ya-Fei Liu, Hao-Yang Wang, Qi-Long Shen*


• Ge, H.; Wu, B.; Liu, Y.; Wang, H.; Shen, Q.*

ACS Catal. 2020, 10, 12414–12424.
10.1021/acscatal.0c03776

100. N-[(Diethoxyphosphoryl)difluoromethylthio]phthalimide: A New Electrophilic Fluoroalkylthiolating Reagent

• Feng Shen,
Long Lü
• *, Qi-Long Shen*


• Shen, F.; Lü, L.*; Shen, Q.*

Acta Chim. Sin. 2020, 78, 933–937.
10.6023/A20060248

99. Electrophilic Fluoroalkylthiolation Induced Diastereoselective and Stereospecific 1,2-Metalate Migration of Alkenylboronate Complexes

• Feng Shen,
Long Lü
• *, Qi-Long Shen*


• Shen, F.; Lü, L.*; Shen, Q.*

Chem. Sci. 2020, 11, 8020–8024.
10.1039/D0SC03039B

98. Monofluoromethyl-Substituted Sulfonium Ylides: Preparation, Structure-Reactivity Study and Substrate Scope

• Xin Hong, Ya-Fei Liu,
Long Lü
• *, Qi-Long Shen*


• Hong, X.; Liu, Y.; Lü, L.*; Shen, Q.*

Chin. J. Chem. 2020, 38, 1317–1331.
10.1002/cjoc.202000206

97. Cobalt-Catalyzed Asymmetric Cross-Coupling Reaction of Fluorinated Secondary Benzyl Bromides with Lithium Aryl Boronates/ZnBr₂
Wei-Chen Huang
• , Xiao-Long Wan, Qi-Long Shen*


• Huang, W.; Wan, X.; Shen, Q.*

Org. Lett. 2020, 22, 4327–4332.
10.1021/acs.orglett.0c01363

96. C(sp³)-CF₃ Reductive Elimination from a Five-Coordinate Neutral Copper(III) Complex

• Shuan-Shuan Liu, He Liu, Shi-Han Liu,
Ze-Hai Lu
• , Chang-Hui Lu,
Xue-Bing Leng
• ,
Yu Lan
• *, Qi-Long Shen*


• Liu, S.; Liu, H.; Liu, S.; Lu, Z.; Lu, C.; Leng, X.; Lan, Y.*; Shen, Q.*

J. Am. Chem. Soc. 2020, 142, 9785–9791.
10.1021/jacs.0c03304

95. Scalable Synthesis of S-Fluoromethyl Benzenesulfonothioate

• Qun-Chao Zhao, Rui-Chao Yao, Wen-Bo Chen,
Long Lü
• *, Qi-Long Shen*


• Zhao, Q.; Yao, R.; Chen, W.; Lü, L.*; Shen, Q.*

Org. Process Res. Dev. 2020, 24, 1090–1094.
10.1021/acs.oprd.0c00101

94. Reagents for Direct Trifluoromethylthiolation

• He Liu,
Hang-Ming Ge
• , Qi-Long Shen*


• Liu, H.; Ge, H.; Shen, Q.*

Emerging Fluorinated Motifs: Synthesis, Properties, and Applications.
10.1002/9783527824342.ch12

93. Two Ligands Transfer from Ag to Pd: En Route to (SIPr)Pd(CF₂H)(X) and Its Application in One-Pot C–H Borylation/Difluoromethylation

• Hai-Wei Zhao, Simon Herbert, Tom Kinzel, Wei Zhang, Qi-Long Shen*


• Zhao, H.; Herbert, S.; Kinzel, T.; Zhang, W.; Shen, Q.*

J. Org. Chem. 2020, 85, 3596–3604.
10.1021/acs.joc.9b03296

2019 (15)

92. Friedel-Crafts Trifluoromethylthiolation of Electron-Rich (Hetero)Arenes with Trifluorometylthio-saccharin in 2,2,2-Trifluoroethanol (TFE)

• Shi-Yao Lu, Wen-Bo Chen*, Qi-Long Shen*


• Lu, S.; Chen, W.*; Shen, Q.*

Chin. Chem. Lett. 2019, 30, 2279–2281.
10.1016/j.cclet.2019.07.060

91. Ethyl 2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)thio]-2,2-difluoroacetate

• Qi-Long Shen


• Shen, Q.

Encyclopedia of Reagents for Organic Synthesis.
10.1002/047084289X.rn02273

90. Asymmetric Difluoromethylthiolation of Carbon Nucleophiles with Optically Pure Difluoromethylthiolating Reagents Derived from Camphorsultam
He Zhang
• , Xiao-Long Wan, Qi-Long Shen*


• Zhang, H.; Wan, X.; Shen, Q.*

Chin. J. Chem. 2019, 37, 1041–1050.
10.1002/cjoc.201900298

89. Transition-Metal-Free ipso-Trifluoromethylthiolation of Lithium Aryl Boronates

• Feng Shen, Han-Liang Zheng,
Xiao-Song Xue
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Long Lü
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• Shen, F.; Zheng, H.; Xue, X.; Lü, L.*; Shen, Q.*

Org. Lett. 2019, 21, 6347–6351.
10.1021/acs.orglett.9b02236

88. Facilitating the Transmetalation Step with Aryl-Zincates in Nickel-Catalyzed Enantioselective Arylation of Secondary Benzylic Halides
Wei-Chen Huang
• , Mei Hu, Xiao-Long Wan, Qi-Long Shen*


• Huang, W.; Hu, M.; Wan, X.; Shen, Q.*

Nat. Commun. 2019, 10, 2963.
10.1038/s41467-019-10851-4

87. Copper-Catalyzed Carbene Insertion into the Sulfur–Sulfur Bond of RS–SCF₂H/SCF₃ under Mild Conditions

• Xin Hong,
Long Lü
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• Hong, X.; Lü, L.*; Shen, Q.*

Synlett 2019, 30, 1602–1606.
10.1055/s-0037-1611839

86. Cobalt-Catalyzed Hydro-Difluoromethylthiolation/Hydro-Trifluoromethylthiolation of Unactivated Alkenes

• Xin-Xin Shao, Xin Hong,
Long Lü
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• Shao, X.; Hong, X.; Lü, L.*; Shen, Q.*

Tetrahedron 2019, 75, 4156–4166.
10.1016/j.tet.2019.05.061

85. Cobalt-Catalyzed Cross-Coupling of Lithium (Hetero)Aryl Zinates with Heteroaryl Chlorides and Bromides

• Shuan-Shuan Liu,
Wei-Chen Huang
• , De-Cai Wang, Ping Wei*, Qi-Long Shen*


• Liu, S.; Huang, W.; Wang, D.; Wei, P.*; Shen, Q.*

Org. Chem. Front. 2019, 6, 2630–2634.
10.1039/C9QO00551J

84. Bistrifluoromethylated Organocuprate [Ph₄P]⁺[Cu(CF₃)₂]^-: Synthesis, Characterization and Its Application for Trifluoromethylation of Activated Heteroaryl Bromides, Chlorides and Iodides

• He Liu, Qi-Long Shen*


• Liu, H.; Shen, Q.*

Org. Chem. Front. 2019, 6, 2324–2328.
10.1039/C9QO00527G

83. A Key Intermediate in Copper-Mediated Arene Trifluoromethylation, [ⁿBu₄N][Cu(Ar)(CF₃)₃]: Synthesis, Characterization, and C(sp²)−CF₃ Reductive Elimination
Ze-Hai Lu
• , He Liu, Shi-Han Liu,
Xue-Bing Leng
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Yu Lan
• *, Qi-Long Shen*


• Lu, Z.; Liu, H.; Liu, S.; Leng, X.; Lan, Y.*; Shen, Q.*

Angew. Chem. Int. Ed. 2019, 58, 8510–8514.
10.1002/anie.201904041

82. [Ag(bpy)(PPh^tBu₂)(OCF₃)]: A Stable Nucleophilic Reagent for Chemoselective and Stereospecific Trifluoromethoxylation of Secondary Alkyl Nosylates

• Dao-Qian Chen,
Long Lü
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• Chen, D.; Lü, L.*; Shen, Q.*

Org. Chem. Front. 2019, 6, 1801–1806.
10.1039/C9QO00278B

81. Methanesulfenic Acid, 1,1,1-Trifluoro-,1-methyl-1-phenylethyl Ester

• Qi-Long Shen


• Shen, Q.

Encyclopedia of Reagents for Organic Synthesis.
10.1002/047084289X.rn02234

80. Synthesis and Reactivity of α-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [¹⁸F]ArylSCF₃
Jiang Wu
• , Qun-Chao Zhao, Thomas C. Wilson, Stefan Verhoog,
Long Lü
• , Véronique Gouverneur*, Qi-Long Shen*


• Wu, J.; Zhao, Q.; Wilson, T. C.; Verhoog, S.; Lü, L.; Gouverneur, V.*; Shen, Q.*

Angew. Chem. Int. Ed. 2019, 58, 2413–2417.
10.1002/anie.201813708

79. Trifluoromethyl-Substituted Selenium Ylide: A Broadly Applicable Electrophilic Trifluoromethylating Reagent
Hang-Ming Ge
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• Ge, H.; Shen, Q.*

Org. Chem. Front. 2019, 6, 2205–2209.
10.1039/C8QO01249K

78. Pentafluoroethyl-Substituted Sulfonium Ylides: New Electrophilic Pentafluoroethylating Reagents

• Ya-Fei Liu,
Hang-Ming Ge
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Long Lü
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• Liu, Y.; Ge, H.; Lü, L.*; Shen, Q.*

Chin. J. Org. Chem. 2019, 39, 257–264.
10.6023/cjoc201807018

2018 (7)

77. The Difluoromethylated Organogold(III) Complex cis-[Au(PCy₃)(4-F-C₆H₄)(CF₂H)(Cl)]: Preparation, Characterization, and Its C(sp²)–CF₂H Reductive Elimination

• Shuan-Shuan Liu,
Kai Kang
• , Shi-Han Liu, De-Cai Wang, Ping Wei*,
Yu Lan
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• Liu, S.; Kang, K.; Liu, S.; Wang, D.; Wei, P.*; Lan, Y.*; Shen, Q.*

Organometallics 2018, 37, 3901–3908.
10.1021/acs.organomet.8b00579

76. Carbon-Selective Difluoromethylation of Soft Carbon Nucleophiles with Difluoromethylated Sulfonium Ylide
Jian-Sheng Zhu
• , Han-Liang Zheng,
Xiao-Song Xue
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Yi-Sa Xiao
• , Ya-Fei Liu, Qi-Long Shen*


• Zhu, J.; Zheng, H.; Xue, X.*; Xiao, Y.; Liu, Y.; Shen, Q.*

Chin. J. Chem. 2018, 36, 1069–1074.
10.1002/cjoc.201800383

75. Pd-Catalyzed Difluoromethylthiolation of Aryl Chlorides, Bromides and Triflates
Jiang Wu
• , Chang-Hui Lu,
Long Lü
• *, Qi-Long Shen*


• Wu, J.; Lu, C.; Lü, L.*; Shen, Q.*

Chin. J. Chem. 2018, 36, 1031–1034.
10.1002/cjoc.201800306

74. Radical Fluoroalkylthiolation of Aldehydes with PhSO₂SR_f (R_f = CF₃, C₂F₅, CF₂H or CH₂F): a General Protocol for the Preparation of Fluoroalkylthioesters

• Bin Xu, De-Zhi Li,
Long Lü
• , De-Cai Wang*, Yong-Hong Hu*, Qi-Long Shen*


• Xu, B.; Li, D.; Lü, L.; Wang, D.*; Hu, Y.*; Shen, Q.*

Org. Chem. Front. 2018, 5, 2163–2166.
10.1039/C8QO00327K

73. Silver-Catalyzed Ring-Opening Difluoromethylthiolation/Trifluoromethylthiolation of Cycloalkanols with PhSO₂SCF₂H or PhSO₂SCF₃

• Bin Xu, De-Cai Wang, Yong-Hong Hu*, Qi-Long Shen*


• Xu, B.; Wang, D.; Hu, Y.*; Shen, Q.*

Org. Chem. Front. 2018, 5, 1462–1465.
10.1039/C8QO00115D

72. Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Triflates and Its Applications in the Preparation of Difluoromethylated Derivatives of Drug/Agrochemical Molecules

• Chang-Hui Lu, Hao Lu,
Jiang Wu
• , Hong C. Shen, Tai-Shan Hu, Yu-Cheng Gu, Qi-Long Shen*


• Lu, C.; Lu, H.; Wu, J.; Shen, H. C.; Hu, T.; Gu, Y.; Shen, Q.*

J. Org. Chem. 2018, 83, 1077–1083.
10.1021/acs.joc.7b02989

71. Ligand-Controlled Copper-Catalyzed Highly Regioselective Difluoromethylation of Allylic Chlorides/Bromides and Propargyl Bromides
Yang Gu
• , Chang-Hui Lu, Yu-Cheng Gu, Qi-Long Shen*


• Gu, Y.; Lu, C.; Gu, Y.; Shen, Q.*

Chin. J. Chem. 2018, 36, 55–58.
10.1002/cjoc.201700594

2017 (10)

70. C(sp²)–C(sp²) Reductive Elimination from Well-Defined Diarylgold(III) Complexes
Kai Kang
• , Shuan-Shuan Liu, Ting Xu, De-Cai Wang,
Xue-Bing Leng
• , Ruo-Peng Bai,
Yu Lan
• *, Qi-Long Shen*


• Kang, K.; Liu, S.; Xu, T.; Wang, D.; Leng, X.; Bai, R.; Lan, Y.*; Shen, Q.*

Organometallics 2017, 36, 4727–4740.
10.1021/acs.organomet.7b00588

69. Recent Progress on Direct Trifluoromethylthiolating Reagents and Methods

• Pan-Pan Zhang,
Long Lü
• *, Qi-Long Shen*


• Zhang, P.; Lü, L.*; Shen, Q.*

Acta Chim. Sinica 2017, 75, 744–769.
10.6023/A17050202

68. Enantioselective Construction of Trifluoromethoxylated Stereogenic Centers by a Nickel-Catalyzed Asymmetric Suzuki–Miyaura Coupling of Secondary Benzyl Bromides
Wei-Chen Huang
• , Xiao-Long Wan, Qi-Long Shen*


• Huang, W.; Wan, X.; Shen, Q.*

Angew. Chem. Int. Ed. 2017, 56, 11986–11989.
10.1002/anie.201706868

67. Direct Monofluoromethylthiolation with S-(Fluoromethyl) Benzenesulfonothioate

• Qun-Chao Zhao,
Long Lü
• *, Qi-Long Shen*


• Zhao, Q.; Lü, L.*; Shen, Q.*

Angew. Chem. Int. Ed. 2017, 56, 11575–11578.
10.1002/anie.201705633

66. A Two-Step, One-Pot, and Multigram-Scale Synthesis of N-Difluoromethylthiophthalimide

• Dian-Hu Zhu, Xin Hong, De-Zhi Li,
Long Lü
• *, Qi-Long Shen*


• Zhu, D.; Hong, X.; Li, D.; Lü, L.*; Shen, Q.*

Org. Process Res. Dev. 2017, 21, 1383–1387.
10.1021/acs.oprd.7b00203

65. Preparation of N-Trifluoromethylthiosaccharin: A Shelf-Stable Electrophilic Reagent for Trifluoromethylthiolation
Jian-Sheng Zhu
• , Chun-Hui Xu,
Chun-Fa Xu
• , Qi-Long Shen*


• Zhu, J.; Xu, C.; Xu, C.; Shen, Q.*

Org. Synth. 2017, 94, 217–233.
10.1002/0471264229.os094.16

64. Monofluoromethyl-Substituted Sulfonium Ylides: Electrophilic Monofluoromethylating Reagents with Broad Substrate Scopes

• Ya-Fei Liu,
Long Lü
• *, Qi-Long Shen*


• Liu, Y.; Lü, L.*; Shen, Q.*

Angew. Chem. Int. Ed. 2017, 56, 9930–9934.
10.1002/anie.201704175

63. Palladium-Catalyzed Difluoromethylation of Heteroaryl Chlorides, Bromides and Iodides

• Chang-Hui Lu,
Yang Gu
• ,
Jian Wu
• , Yu-Cheng Gu, Qi-Long Shen*


• Lu, C.; Gu, Y.; Wu, J.; Gu, Y.; Shen, Q.*

Chem. Sci. 2017, 8, 4848–4852.
10.1039/C7SC00691H

62. [[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide: A Shelf-Stable, Electrophilic Reagent with a Convertible Group for the Synthesis of Diversified Fluoroalkylthiolated Compounds

• Feng Shen, Pan-Pan Zhang,
Long Lü
• *, Qi-Long Shen*


• Shen, F.; Zhang, P.; Lü, L.*; Shen, Q.*

Org. Lett. 2017, 19, 1032–1035.
10.1021/acs.orglett.7b00010

61. (1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its Derivatives: Easily Available, Optically Pure Reagents for Asymmetric Trifluoromethylthiolation
He Zhang
• ,
Xue-Bing Leng
• , Xiao-Long Wan, Qi-Long Shen*


• Zhang, H.; Leng, X.; Wan, X.; Shen, Q.*

Org. Chem. Front. 2017, 4, 1051–1057.
10.1039/C7QO00042A

2016 (7)

60. PhSO₂SCF₂H: A Shelf-Stable, Easily Scalable Reagent for Radical Difluoromethylthiolation

• Dian-Hu Zhu, Xin-Xin Shao, Xin Hong,
Long Lü
• *, Qi-Long Shen*


• Zhu, D.; Shao, X.; Hong, X.; Lü, L.*; Shen, Q.*

Angew. Chem. Int. Ed. 2016, 55, 15807–15811.
10.1002/anie.201609468

59. N-Trifluoromethylthio-dibenzenesulfonimide: A Shelf-Stable, Broadly Applicable Electrophilic Trifluoromethylthiolating Reagent

• Pan-Pan Zhang, Man Li,
Xiao-Song Xue
• *,
Chun-Fa Xu
• , Qun-Chao Zhao, Ya-Fei Liu, Hao-Yang Wang, Yin-Long Guo,
Long Lü
• *, Qi-Long Shen*


• Zhang, P.; Li, M.; Xue, X.*; Xu, C.; Zhao, Q.; Liu, Y.; Wang, H.; Guo, Y.; Lü, L.*; Shen, Q.*

J. Org. Chem. 2016, 81, 7486–7509.
10.1021/acs.joc.6b01178

58. Direct Difluoromethylation of Alcohols with an Electrophilic Difluoromethylated Sulfonium Ylide
Jian-Sheng Zhu
• , Ya-Fei Liu, Qi-Long Shen*


• Zhu, J.; Liu, Y.; Shen, Q.*

Angew. Chem. Int. Ed. 2016, 55, 9050–9054.
10.1002/anie.201603166

57. Nucleophilic Trifluoromethylthiolation of Alkyl Chlorides, Bromides and Tosylates
Chun-Fa Xu
• , Qing-Yun Chen, Qi-Long Shen*


• Xu, C.; Chen, Q.; Shen, Q.*

Chin. J. Chem. 2016, 34, 495–504.
10.1002/cjoc.201500905

56. ((2-(2-Iodophenyl)propan-2-yl)oxy)(trifluoromethyl)sulfane

• Qi-Long Shen


• Shen, Q.

Encyclopedia of Reagents for Organic Synthesis.
10.1002/047084289X.rn01928

55. Pentafluoroethylbenziodoxole (BIX-C₂F₅): A Shelf-Stable Reagent for Pentafluoroethylation of β-Ketoesters and Arylboronic Acids
Jian-Sheng Zhu
• ,
Yu-Guang Li
• , Chuan-Fa Ni, Qi-Long Shen*


• Zhu, J.; Li, Y.; Ni, C.; Shen, Q.*

Chin. J. Chem. 2016, 34, 662–668.
10.1002/cjoc.201600097

54. Palladium-Catalyzed Difluoromethylthiolation of Heteroaryl Bromides, Iodides, Triflates and Aryl Iodides
Jiang Wu
• , Ya-Fei Liu, Chang-Hui Lu, Qi-Long Shen*


• Wu, J.; Liu, Y.; Lu, C.; Shen, Q.*

Chem. Sci. 2016, 7, 3757–3762.
10.1039/C6SC00082G

2015 (10)

53. Iron-Catalyzed Markovnikov-Selective Hydrotrifluoromethylthiolation of Unactivated Alkenes

• Tao Yang,
Long Lü
• *, Qi-Long Shen*


• Yang, T.; Lü, L.*; Shen, Q.*

Chem. Commun. 2015, 51, 5479–5481.
10.1039/C4CC08655D

52. Lewis Acid Mediated Trifluoromethylthio Lactonization/Lactamization
Chun-Fa Xu
• , Qi-Long Shen*


• Xu, C.; Shen, Q.*

Org. Lett. 2015, 17, 4561–4563.
10.1021/acs.orglett.5b02315

51. N-Difluoromethylthiophthalimide: A Shelf-Stable, Electrophilic Reagent for Difluoromethylthiolation

• Dian-Hu Zhu,
Yang Gu
• ,
Long Lü
• *, Qi-Long Shen*


• Zhu, D.; Gu, Y.; Lü, L.*; Shen, Q.*

J. Am. Chem. Soc. 2015, 137, 10547–10553.
10.1021/jacs.5b03170

50. Well-Defined, Shelf-Stable (NHC)Ag(CF₂H) Complexes for Difluoromethylation
Yang Gu
• ,
Da-Lu Chang
• ,
Xue-Bing Leng
• , Yu-Cheng Gu, Qi-Long Shen*


• Gu, Y.; Chang, D.; Leng, X.; Gu, Y.; Shen, Q.*

Organometallics 2015, 34, 3065–3071.
10.1021/acs.organomet.5b00350

49. Trifluoromethyl-Substituted Sulfonium Ylide: Rh-Catalyzed Carbenoid Addition to Trifluoromethylthioether

• Ya-Fei Liu, Xin-Xin Shao, Pan-Pan Zhang,
Long Lü
• *, Qi-Long Shen*


• Liu, Y.; Shao, X.; Zhang, P.; Lü, L.*; Shen, Q.*

Org. Lett. 2015, 17, 2752–2755.
10.1021/acs.orglett.5b01170

48. Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts
Jiang Wu
• ,
Yang Gu
• ,
Xue-Bing Leng
• , Qi-Long Shen*


• Wu, J.; Gu, Y.; Leng, X.; Shen, Q.*

Angew. Chem. Int. Ed. 2015, 54, 7648–7652.
10.1002/anie.201502113

47. Shelf-Stable Electrophilic Reagents for Trifluoromethylthiolation

• Xin-Xin Shao,
Chun-Fa Xu
• ,
Long Lü
• , Qi-Long Shen*


• Shao, X.; Xu, C.; Lü, L.; Shen, Q.*

Acc. Chem. Res. 2015, 48, 1227–1236.
10.1021/acs.accounts.5b00047

46. Pd-Catalyzed Difluoromethylation of Vinyl Bromides, Triflates, Tosylates, and Nonaflates
Da-Lu Chang
• ,
Yang Gu
• , Qi-Long Shen*


• Chang, D.; Gu, Y.; Shen, Q.*

Chem. Eur. J. 2015, 21, 6074–6078.
10.1002/chem.201500551

45. Structure–Reactivity Relationship of Trifluoromethanesulfenates: Discovery of an Electrophilic Trifluoromethylthiolating Reagent

• Xin-Xin Shao,
Chun-Fa Xu
• ,
Long Lü
• *, Qi-Long Shen*


• Shao, X.; Xu, C.; Lü, L.*; Shen, Q.*

J. Org. Chem. 2015, 80, 3012–3021.
10.1021/jo502645m

44. Brønsted Acid-Catalyzed Electrophilic Trifluoromethylthiolation of Indoles Using Thermally Stable Trifluoromethylthiolating Reagent
Bing-Qing Ma
• , Xin-Xin Shao, Qi-Long Shen*


• Ma, B.; Shao, X.; Shen, Q.*

J. Fluorine Chem. 2015, 171, 73–77.
10.1016/j.jfluchem.2014.09.011

2014 (8)

43. Cooperative Dual Palladium/Silver Catalyst for Direct Difluoromethylation of aryl Bromides and Iodides
Yang Gu
• ,
Xue-Bing Leng
• , Qi-Long Shen*


• Gu, Y.; Leng, X.; Shen, Q.*

Nat. Commun. 2014, 5, 5405.
10.1038/ncomms6405

42. Nickel-Catalyzed α-Arylation of Zinc Enolates with Polyfluoroarenes via C–F Bond Activation under Neutral Conditions

• Dao-Hong Yu, Chang-Sheng Wang, Cheng Yao, Qi-Long Shen*,
Long Lü
• *


• Yu, D.; Wang, C.; Yao, C.; Shen, Q.*; Lü, L.*

Org. Lett. 2014, 16, 5544–5547.
10.1021/ol502499q

41. Copper-Catalyzed Trifluoromethylthiolation of Primary and Secondary Alkylboronic Acids

• Xin-Xin Shao,
Tian-Fei Liu
• ,
Long Lü
• *, Qi-Long Shen*


• Shao, X.; Liu, T.; Lü, L.*; Shen, Q.*

Org. Lett. 2014, 16, 4738–4741.
10.1021/ol502132j

40. Chincona Alkaloid-Catalyzed Enantioselective Trifluoromethylthiolation of Oxindoles

• Tao Yang, Qi-Long Shen*,
Long Lü
• *


• Yang, T.; Shen, Q.*; Lü, L.*

Chin. J. Chem. 2014, 32, 678–680.
10.1002/cjoc.201400392

39. N-Trifluoromethylthiosaccharin: An Easily Accessible, Shelf-Stable, Broadly Applicable Trifluoromethylthiolating Reagent
Chun-Fa Xu
• ,
Bing-Qing Ma
• , Qi-Long Shen*


• Xu, C.; Ma, B.; Shen, Q.*

Angew. Chem. Int. Ed. 2014, 53, 9316–9320.
10.1002/anie.201403983

38. Silver-Catalyzed Decarboxylative Trifluoromethylthiolation of Aliphatic Carboxylic Acids in Aqueous Emulsion

• Feng Hu, Xin-Xin Shao, Dian-Hu Zhu,
Long Lü
• , Qi-Long Shen*


• Hu, F.; Shao, X.; Zhu, D.; Lü, L.; Shen, Q.*

Angew. Chem. Int. Ed. 2014, 53, 6105–6109.
10.1002/anie.201402573

37. Palladium-Catalyzed Trifluoromethylthiolation of Aryl C–H Bonds
Chun-Fa Xu
• , Qi-Long Shen*


• Xu, C.; Shen, Q.*

Org. Lett. 2014, 16, 2046–2049.
10.1021/ol5006533

36. Copper-Catalyzed Trifluoromethylthiolation of Aryl and Vinyl Boronic Acids with a Shelf-Stable Electrophilic Trifluoromethylthiolating Reagent
Kai Kang
• ,
Chun-Fa Xu
• , Qi-Long Shen*


• Kang, K.; Xu, C.; Shen, Q.*

Org. Chem. Front. 2014, 1, 294–297.
10.1039/C3QO00068K

2013 (6)

35. Enantioselective Electrophilic Trifluoromethylthiolation of β-Ketoesters: A Case of Reactivity and Selectivity Bias for Organocatalysis

• Xue-Qiang Wang, Tao Yang, Xiao-Lin Cheng, Qi-Long Shen*


• Wang, X.; Yang, T.; Cheng, X.; Shen, Q.*

Angew. Chem. Int. Ed. 2013, 52, 12860–12864.
10.1002/anie.201305075

34. Palladium-Catalyzed Cross-Coupling of Fluorinated Vinyl Chlorides with Terminal Alkynes: A General Protocol to Fluorinated Enynes

• Sheng Chen,
Chun-Fa Xu
• ,
Long Lü
• , Qi-Long Shen*


• Chen, S.; Xu, C.; Lü, L.; Shen, Q.*

Chin. J. Chem. 2013, 31, 901–907.
10.1002/cjoc.201300352

33. A General and Highly Selective Method for the Asymmetric Synthesis of Trifluoromethyl-Substituted α- and β-Aminophosphonates

• Li-Jing Wang, Qi-Long Shen,
Long Lü
• *


• Wang, L.; Shen, Q.; Lü, L.*

Chin. J. Chem. 2013, 31, 892–900.
10.1002/cjoc.201300344

32. Palladium-Catalyzed Coupling of Polyfluorinated Arenes with Heteroarenes via C–F/C–H Activation

• Dao-Hong Yu,
Long Lü
• *, Qi-Long Shen*


• Yu, D.; Lü, L.*; Shen, Q.*

Org. Lett. 2013, 15, 940–943.
10.1021/ol303567t

31. Enantioselective Organocatalytic Michael Addition of Nitroalkanes and Other Nucleophiles to β-Trifluoromethylated Acrylamides

• Le-Le Wen, Liang Yin, Qi-Long Shen*,
Long Lü
• *


• Wen, L.; Yin, L.; Shen, Q.*; Lü, L.*

ACS Catal. 2013, 3, 502–506.
10.1021/cs300806w

30. An Electrophilic Hypervalent Iodine Reagent for Trifluoromethylthiolation

• Xin-Xin Shao, Xue-Qiang Wang, Tao Yang,
Long Lü
• *, Qi-Long Shen*


• Shao, X.; Wang, X.; Yang, T.; Lü, L.*; Shen, Q.*

Angew. Chem. Int. Ed. 2013, 52, 3457–3460.
10.1002/anie.201209817

2012 (11)

29. Preparation of Trifluorostyrenes via Palladium-Catalyzed Coupling of Arylboronic Acids with Chloro- and Bromotrifluoroethylene

• Tao-Ping Liu, Xiao-Ming Zhao, Qi-Long Shen,
Long Lü
• *


• Liu, T.; Zhao, X.; Shen, Q.; Lü, L.*

J. Org. Chem. 2012, 77, 10314–10320.
10.1021/jo301998g

28. Progress in Copper-Mediated Formation of Trifluoromethylated Arenes
Tian-Fei Liu
• ,
Long Lü
• *


• Liu, T.; Lü, L.*

Eur. J. Org. Chem. 2012, 2012, 6679–6687.
10.1002/ejoc.201200648

27. Bis(perfluoroalkyl) Phosphino-Oxazoline: A Modular, Stable, Strongly π-Accepting Ligand for Asymmetric Catalysis
Zong-Jian Hu
• ,
Yu-Guang Li
• ,
Kai Liu
• , Qi-Long Shen*


• Hu, Z.; Li, Y.; Liu, K.; Shen, Q.*

J. Org. Chem. 2012, 77, 7957–7967.
10.1021/jo3011717

26. Highly Selective Activation of Vinyl C–S Bonds Over Aryl C–S Bonds in the Pd-Catalyzed Coupling of (E)-(β-Trifluoromethyl)vinyldiphenylsulfonium Salts: Preparation of Trifluoromethylated Alkenes and Dienes

• Hao Lin, Xi-Cheng Dong, Yu-Xue Li*, Qi-Long Shen*,
Long Lü
• *


• Lin, H.; Dong, X.; Li, Y.*; Shen, Q.*; Lü, L.*

Eur. J. Org. Chem. 2012, 2012, 4675–4679.
10.1002/ejoc.201200758

25. General and Highly Efficient Fluorinated-N-Heterocyclic Carbene-Based Catalysts for the Palladium-Catalyzed Suzuki–Miyaura Reaction

• Tao-Ping Liu, Xiao-Ming Zhao, Qi-Long Shen,
Long Lü
• *


• Liu, T.; Zhao, X.; Shen, Q.; Lü, L.*

Tetrahedron 2012, 68, 6535–6547.
10.1016/j.tet.2012.05.068

24. Copper-Mediated Aerobic Fluoroalkylation of Arylboronic Acids with Fluoroalkyl Iodides at Room Temperature

• Qing-Qing Qi, Qi-Long Shen*,
Long Lü
• *


• Qi, Q.; Shen, Q.*; Lü, L.*

J. Am. Chem. Soc. 2012, 134, 6548–6551.
10.1021/ja301705z

23. Transition Metal-Catalyzed Arene Trifluoromethylation

• Cui-Ping Lü, Qi-Long Shen, Dan Liu*


• Lü, C.; Shen, Q.; Liu, D.*

Chin. J. Org. Chem. 2012, 32, 1380–1387.
10.6023/cjoc1110151

22. Selective Palladium-Catalyzed C−F Activation Carbon−Carbon Bond Formation of Polyfluoroaryl Oxazolines

• Dao-Hong Yu, Qi-Long Shen*,
Long Lü
• *


• Yu, D.; Shen, Q.*; Lü, L.*

J. Org. Chem. 2012, 77, 1798–1804.
10.1021/jo2023262

21. Highly Selective Trifluoromethylation of 1,3-Disubstituted Arenes through Iridium-Catalyzed Arene Borylation
Tian-Fei Liu
• , Xin-Xin Shao, Ya-Ming Wu, Qi-Long Shen*


• Liu, T.; Shao, X.; Wu, Y.; Shen, Q.*

Angew. Chem. Int. Ed. 2012, 51, 540–543.
10.1002/anie.201106673

20. A Facile Synthetic Route to 2-Trifluromethyl-Substituted Polyfunctionalized Chromenes and Chromones

• Le-Le Wen, Hong-Hai Zhang, Hao Lin, Qi-Long Shen*,
Long Lü
• *


• Wen, L.; Zhang, H.; Lin, H.; Shen, Q.*; Lü, L.*

J. Fluorine Chem. 2012, 133, 171–177.
10.1016/j.jfluchem.2011.10.011

19. Polyfluoroalkylation of 2-Aminothiazoles

• Qing-Qing Qi, Qi-Long Shen,
Long Lü
• *


• Qi, Q.; Shen, Q.; Lü, L.*

J. Fluorine Chem. 2012, 133, 115–119.
10.1016/j.jfluchem.2011.07.005

2011 (6)

18. The Recent Development of Organofluorine Chemistry in China: Asymmetric Construction of Stereogenic Trifluoromethyl-Substituted Carbon Centers

• Le-Le Wen, Qi-Long Shen,
Long Lü
• *


• Wen, L.; Shen, Q.; Lü, L.*

Chimia 2011, 65, 894–901.
10.2533/chimia.2011.894

17. Polyfluoroalkylation of 2-Aminothiazoles: Unexpected sp³ C–Cl Substitution under Mild Conditions

• Qing-Qing Qi, Qi-Long Shen,
Long Lü
• *


• Qi, Q.; Shen, Q.; Lü, L.*

Chin. J. Chem. 2011, 29, 2681–2683.
10.1002/cjoc.201180439

16. β-(Trifluoromethyl)vinyl Sulfonium Salts: Preparation and Reactions with Active Methylene and Methenyl Compounds

• Hao Lin, Qi-Long Shen,
Long Lü
• *


• Lin, H.; Shen, Q.; Lü, L.*

J. Org. Chem. 2011, 76, 7359–7369.
10.1021/jo2009033

15. Copper-Catalyzed Trifluoromethylation of Aryl and Vinyl Boronic Acids with An Electrophilic Trifluoromethylating Reagent
Tian-Fei Liu
• , Qi-Long Shen*


• Liu, T.; Shen, Q.*

Org. Lett. 2011, 13, 2342–2345.
10.1021/ol2005903

14. Enantioselective Friedel−Crafts Alkylation of Indoles with Trifluoroethylidene Malonates by Copper−Bis(oxazoline) Complexes: Construction of Trifluoromethyl-Substituted Stereogenic Tertiary Carbon Center

• Le-Le Wen, Qi-Long Shen, Xiao-Long Wan,
Long Lü
• *


• Wen, L.; Shen, Q.; Wan, X.; Lü, L.*

J. Org. Chem. 2011, 76, 2282–2285.
10.1021/jo1024333

13. Highly Diastereoselective Synthesis of Optically Pure Trifluoromethyl-Substituted Imidazolidine, Oxazolidine and Thiazolidine

• Hong-Hai Zhang, Qi-Long Shen,
Long Lü
• *


• Zhang, H.; Shen, Q.; Lü, L.*

Tetrahedron Lett. 2011, 52, 349–351.
10.1016/j.tetlet.2010.11.061

2010 (1)

12. Enantioselective Organocatalytic Michael Addition of Aldehydes to Trifluoroethylidene Malonates

• Le-Le Wen, Qi-Long Shen,
Long Lü
• *


• Wen, L.; Shen, Q.; Lü, L.*

Org. Lett. 2010, 12, 4655–4657.
10.1021/ol101894h

before 2010 (11)

11. Mechanically-Induced Chemical Changes in Polymeric Materials

• Mary M. Caruso, Douglas A. Davis,
Qi-Long Shen
• , Susan A. Odom, Nancy R. Sottos, Scott R. White, Jeffrey S. Moore*


• Caruso, M. M.; Davis, D. A.;
Shen, Q.
• ; Odom, S. A.; Sottos, N. R.; White, S. R.; Moore, J. S.*

Chem. Rev. 2009, 109, 5755–5798.
10.1021/cr9001353

10. [(CyPF-^tBu)PdCl₂]: An Air-Stable, One-Component, Highly Efficient Catalyst for Amination of Heteroaryl and Aryl Halides
Qi-Long Shen
• ,
John F. Hartwig
• *

Shen, Q.
• ; Hartwig, J. F.*

Org. Lett. 2008, 10, 4109–4112.
10.1021/ol801615u

9. Highly Reactive, General and Long-Lived Catalysts for Palladium-Catalyzed Amination of Heteroaryl and Aryl Chlorides, Bromides, and Iodides: Scope and Structure–Activity Relationships
Qi-Long Shen
• , Tokutaro Ogata,
John F. Hartwig
• *

Shen, Q.
• ; Ogata, T.; Hartwig, J. F.*

J. Am. Chem. Soc. 2008, 130, 6586–6596.
10.1021/ja077074w
(This paper was highlighted in Synfacts, 2008, 8, 859 as synfact of the month.)

8. Lewis Acid Acceleration of C−N Bond-Forming Reductive Elimination from Heteroaryl Palladium Complexes and Catalytic Amidation of Heteroaryl Bromides
Qi-Long Shen
• ,
John F. Hartwig
• *

Shen, Q.
• ; Hartwig, J. F.*

J. Am. Chem. Soc. 2007, 129, 7734–7735.
10.1021/ja0722473

7. Palladium-Catalyzed Coupling of Ammonia and Lithium Amide with Aryl Halides
Qi-Long Shen
• ,
John F. Hartwig
• *

Shen, Q.
• ; Hartwig, J. F.*

J. Am. Chem. Soc. 2006, 128, 10028–10029.
10.1021/ja064005t
(This publication was listed as one of the most-accessed communications in J. Am. Chem. Soc. for the July-September 2006 period. This paper was also featured in C&E News, 2006, 84, 32. In addition, this paper was highlighted in Angew. Chem. Int. Ed. 2007, 46, 3402–3404.)

6. Highly Efficient and Functional-Group-Tolerant Catalysts for the Palladium-Catalyzed Coupling of Aryl Chlorides with Thiols

• Manuel A. Fernández-Rodríguez,
Qi-Long Shen
• ,
John F. Hartwig
• *


• Fernández-Rodríguez, M. A.;
Shen, Q.
• ; Hartwig, J. F.*

Chem. Eur. J. 2006, 12, 7582–7596.
10.1002/chem.200600949

5. A General and Long-Lived Catalyst for the Palladium-Catalyzed Coupling of Aryl Halides with Thiols

• Manuel A. Fernández-Rodríguez,
Qi-Long Shen
• ,
John F. Hartwig
• *


• Fernández-Rodríguez, M. A.;
Shen, Q.
• ; Hartwig, J. F.*

J. Am. Chem. Soc. 2006, 128, 2180–2181.
10.1021/ja0580340

4. Highly Reactive, General, and Long-Lived Catalysts for Coupling Heteroaryl and Aryl Chlorides with Primary Nitrogen Nucleophiles
Qi-Long Shen
• , Shashank Shekhar, James P. Stambuli,
John F. Hartwig
• *

Shen, Q.
• ; Shekhar, S.; Stambuli, J. P.; Hartwig, J. F.*

Angew. Chem. Int. Ed. 2005, 44, 1371–1375.
10.1002/anie.200462629

3. Regiospecific Synthesis of Bicyclo- and Heterobicyclo-gem-Difluorocyclobutenes Using Functionalized Fluoroallenes and a Novel Mo-Catalyzed Intramolecular [2 + 2] Cycloaddition Reaction
Qi-Long Shen
• ,
Gerald B. Hammond
• *

Shen, Q.
• ; Hammond, G. B.*

J. Am. Chem. Soc. 2002, 124, 6534–6535.
10.1021/ja0263893

2. Synthesis and X-ray Information of Substituted gem-Difluoroallenyl Amines
Qi-Long Shen
• , Chbun-Hsing Chen,
Gerald B. Hammond
• *

Shen, Q.
• ; Chen, C.; Hammond, G. B.*

J. Fluorine Chem. 2002, 117, 131–135.
10.1016/S0022-1139(02)00158-6

1. Highly Efficient Synthesis of 1,1-Difluoro-2-substituted-1,3-dienes and Dienynes from gem-Difluorohomoallenyl Bromide via Palladium-Catalyzed Cross-Coupling Reaction
Qi-Long Shen
• ,
Gerald B. Hammond
• *

Shen, Q.
• ; Hammond, G. B.*

Org. Lett. 2001, 3, 2213–2215.
10.1021/ol0160654